Abstract

<p>Time series of mRNA levels of TNFAIP3, IκBα, RIG-I and IFNβ following stimulation by 4 µg dsRNA in hAECs cells for 0, 0.5, 1, 2, 4, and 6 hr. Gene expression estimated using Q-RT-PCR was as described previously <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0093396#pone.0093396-Liu1" target="_blank">[10]</a>. Experimental measurements, black circles with empirical 95% confidence intervals based on triplicate measurements; means of 100 simulated single-cell trajectories, blue lines; 95% confidence bands based on simulations, red lines. Two types of simulations presented (A) under extrinsic noise, (B) under extrinsic and intrinsic noise. Horizontal axis - time (hr); vertical axis - number of molecules. Absolute values of experimental measurements scaled to simulation data (see the text for details).</p

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