Protein domains and immunologically-relevant regions of <i>pvmsp-1</i> 42 kDa region and <i>pvcsp</i>.

Abstract

<p>For both genes, numbers indicate coordinates according to the Sal1 reference genes. Sequences for <i>pvmsp-1</i> (PVX_099980) and pvcsp (PVX_119355) were accessed August 14, 2012 from PlasmoDB.org. (<b>A</b>) The <i>pvmsp-1</i> 42 kDa region is composed of two primary subunits – a 33 kDa and a 19 kDa subunit. Other sub-regions, including the 20 kDa and 14 kDa HARBs have been previously defined and studied. Here, we define the region between the HARBs as the “intervening region.” (<b>B</b>) The <i>pvcsp</i> gene is composed of three regions – an N-terminal non-repeat region, a central repeat region, and a C-terminal non-repeat region. The central repeat region consists of two major nonapeptide repeat types, termed VK210 and VK247. Approximate locations of <i>pvcsp</i> regions I and II are noted with horizontal lines in the N- and C-terminal non-repeat regions, respectively.</p