Framework of TSNBA. PPI network and gene expression data are integrated in the interaction activity matrix to rank genes for their relevancy to the perturbation.

Abstract

<p>The top K ranking genes are further filtered with co-expression network for better pathology enrichment. Context likelihood of relatedness (CLR) algorithm is used in the third step to infer gene regulatory networks and identify key transcription regulators. Node in gray represents for known pathology related genes, white represents for predicted ones, and black represents for predicted key regulators.</p

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