Effect of dopamine on the EPSC.

Abstract

<p><b>A</b>: Current traces of the response evoked by single electrical stimulus recorded at holding potentials of −20 mV (upper row) and −100 mV (lower row) before (1), during (2), and after (3) superfusion with dopamine (DA 50 µM). 4: the overlay of the responses before and during DA superfusion. Current traces represent the average of 6 sweeps. Recordings were obtained in a slice from a P7 animal. Left and right vertical arrows in 1 indicate where the AMPA/KA and NMDA responses were measured. <b>B</b>: Average current-voltage relationship of the AMPA/KA (n = 51; 1) and NMDA (n = 51; 2) responses recorded before and during superfusion with DA. The I<sub>R</sub>-V<sub>m</sub> of the late response were aligned on the holding membrane potential at which the response was maximum before averaging (usually at −20 mV or −40 mV). Asterisks indicate a statistically significant difference between control and DA treatment at this holding membrane potential (Student’s <i>t</i>-test, <i>P</i><0.05).</p

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