IFNα prevents and reverses experimental PH.

Abstract

<p>(A) Effect of IFNα on RVSP and (B, C) RVH in SUH rats treated with IFNα or vehicle (n = 6 rats per group). (D–F) Representative Images of hearts from normoxic, 5 week SUH, and 5 week SUH rats treated with IFNα. Effect of IFNα on (G) RVSP and (H–I) RVH in hypoxic mice treated with IFNα or vehicle (n = 8 mice per group). Analysis of variance *<i>P</i><0.05.</p