PCR-8 nontypeable isolates contain inactivating mutations in <i>wchA</i>.

Abstract

<p>A. Schematic of the serotype 8 <i>cps</i> locus (GenBank accession No. AJ239004). Alternative nomenclature is shown for regulatory genes. B. Molecular model of WchA as predicted by TMPRED (<a href="http://www.ch.embnet.org/software/TMPRED_form.html" target="_blank">http://www.ch.embnet.org/software/TMPRED_form.html</a>). Black arrows indicate nonsense (*) and frameshift (**) mutations; gray arrows indicate missense mutations. Residue numbers correspond to the predicted primary amino acid sequence for WchA.</p