Human IFNα attenuates PH in mice in a IFNAR-dependent fashion.

Abstract

<p>Effect of IFNα on (A) RVSP and (B) RVH in normoxic and hypoxic WT or IFNAR1 −/− mice (n = 6 mice per group). (C) Relative expression of IFNα (normalized to GAPDH) in total lung from C57BL/6J mice exposed to 0, 7, or 21 days of CH as determined by qRT-PCR. (D) Serum concentration of IFNα in C57BL/6J mice exposed to 0, 7, or 21 days CH as determined by ELISA. n = 8 animals per group. Analysis of variance *P<0.05. (E) Serum concentration of IFNα in control vs. IPAH human serum as determined by ELISA.</p