Spurious associations at TCR and IGH loci.
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Abstract
<p>Age at sampling (x-axis) versus CNV intensity signal (y-axis) for the three most associated Immunoglobin Heavy (IGH) and T cell receptor (TCR) loci CNVs. Each point represents an individual in the study (irrespective of familial/T1D status). Blue crosses indicate DNA extracted from LCLs (N = 551) and red crosses DNA extracted from blood (N = 2,981). Red and blue lines have been fitted to the LCL/blood data using cubic splines. A - CNVR6085.1 (chr14:21977832-21987926) mapping to TCR alpha and TCR delta locus on chr14, FBAT-CNV P = 3.6 10<sup>−63</sup>. The plot shows correlation between age at sampling and probe intensity for DNA extracted from blood samples. B - CNVR3590.1 (chr7:142194021-142204412) mapping to TCR beta locus on chr7, FBAT-CNV P = 4.4 10<sup>−31</sup>. The plot shows correlation between age at sampling and probe intensity for DNA extracted from blood samples. C - CNVR6294.22 (chr14:105433837-105441555) mapping to Ig heavy chain locus on chr14, FBAT-CNV P = 6.5 10<sup>−5</sup>. No age-dependent effect was detected at this locus.</p
