fC-MSC inhibit the apoptosis in rats with acute myocardial injury.

Abstract

<p>(a) Representative immunofluorescence photomicrographs of saline and fC-MSC treated hearts 4 weeks after fC-MSC therapy showing (a-i & b-i) Overlay; (a-ii & b-ii) Tunel positive cells (green dye) counter stain with (a-iii & b-iii) Hoechst dye respectively (B) TUNEL apoptotic index showing significant decrease in apoptotic cells in fC-MSC treated compared to saline treated hearts. Values shown are mean ± SEM (n = 6). **P<0.01 fC-MSC treated vs saline treated hearts. (C) Representative immune-blots showing expression of BAX and BCL2 in saline and fC-MSC treated rats and (D) their relative density. Densitometric analysis was applied for comparison of relative protein expression. Values expressed Mean ± SE (n = 6), *P<0.05, **P<0.01, ***P<0.001: fC-MSC treated vs. saline treated group.</p