Microwave Assisted Tandem Heck–Sonogashira Reactions of <i>N,N</i>-Di-Boc-Protected 6‑Amino-5-iodo-2-methyl Pyrimidin-4-ol in An Efficient Approach to Functionalized Pyrido[2,3‑<i>d</i>]Pyrimidines

Abstract

A microwave assisted tandem Heck–Sonogashira cross-coupling reaction between 6-<i>N,N</i>-di-Boc-amino-5-iodo-2-methyl pyrimidin-4-ol and various aryl alkynyl substrates has been developed. This process generates novel 5-enynyl substituted pyrimidines, which can be transformed to novel functionalized pyrido­[2,3-<i>d</i>]­pyrimidines by way of a silver catalyzed cyclization reaction