STAT3 Activation does not occur in non-damaged brain regions in multiple models of neurotoxicity.

Abstract

<p>Mice were administered METH, KA or TMT with saline (0.9%) as a control and were killed by focused microwave irradiation at 12 hrs. post dosing and by decapitation at 72 hours post dosing. Multiple “non-target” brain regions for each neurotoxicant were sampled for activated STAT3 (12 hours post dosing) and levels of GFAP (72 hours post dosing). All data points represent mean ± SEM, N = 5. Statistical significance was measured by one-way ANOVA. Where significant differences were found, Fisher's LSD Method of post hoc analysis was performed. Statistical significance of at least p<0.05 for the neurotoxicant exposed groups in comparison to saline controls is denoted by *. See Methods for dosing regimen (multi-dose METH).</p