Transition-Metal-Free C–S Bond Formation: A
Facile Access to Aryl Sulfones from Sodium Sulfinates via Arynes
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Abstract
Sulfones
have been attractive targets for synthetic organic chemists
owing to their immense applications in medicinal, material, and synthetic
chemistry. In this context, an efficient transition-metal-free process
has been demonstrated, wherein a broad range of alkyl/aryl/heteroaryl
sodium sulfinates react with varyingly substituted aryne precursors
(<i>o</i>-silyl aryl triflates) under mild reaction conditions
to afford structurally diverse sulfones in good to excellent yields