Selection candidates involved in the HIF pathway that were found to show evidence of positive selection in highland wolves.

Abstract

<p>Solid lines indicate a direct relationship between enzymes and metabolites. Dashed lines indicate that more than one step is involved in the process. The genes outlined in black boxes were under selection and those indicated in gray boxes were provided for reference. See <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004466#s3" target="_blank">discussion</a> of interactions in the text.</p