Copper-Catalyzed Three-Component Cyanotrifluoromethylation/Azidotrifluoromethylation
and Carbocyclization of 1,6-Enynes
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Abstract
A novel three-component
strategy for the cyanotrifluoromethylation/azidotrifluoromethylation
and carbocyclization of 1,6-enynes is developed. The reaction proceeds
smoothly under a moderate temperature by using a copper catalyst,
which provides a rapid and concise access to addition–carbocyclization
products. Furthermore, the products obtained can be useful building
blocks in discoveries of lead compounds and other biologically active
CF<sub>3</sub>-containing heterocycles