ROS induced NLRP3 inflammsome activation.
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Abstract
<p>(A) Quantitative analysis of the ROS production in H9c2 cells treated with medium and high glucose. (B–D) Western blot analysis of pNF-kB and TXNIP. (E) The production of cellular ROS after NAC treatment. The protein levels of pNF-kB (F and G), TXNIP (G and H), NLRP3 (I and J), ASC (I and K), pro-caspase-1 (I and L), activated caspase-1(I and M), pro-IL-1β (I and N) and mature IL-1β (I and O). Data were presented as means±SEM, from 3 independent experiments. **p<0.01 vs. Ctrl; <sup>##</sup>p<0.01 vs. MG; <sup>§§</sup>p<0.01 vs. HG+vehicle.</p