<p>(A) Terms in a phenotype ontology have an information content (IC) which is inversely proportional to the number of genes annotated with them. The semantic similarity between any two terms equals to the IC of their closest common ancestor term(s). (B) Gene–gene linkages derived from a data type are assessed and rescored according to the semantic similarity of the linked genes' mouse phenotype annotations. (C) The similarity in human phenotype annotations from the HPO is a benchmark on which all the data types can be compared, revealing their relative accuracy and coverage.</p
