A General
Synthesis of Ynones from Aldehydes via Oxidative
C–C bond Cleavage under Aerobic Conditions
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Abstract
We
describe a direct synthesis of various ynones from readily available
aldehydes and hypervalent alkynyl iodides. In this method, a gold
catalyst and a secondary amine work synergistically to produce the
trisubstituted allenyl aldehyde, which can be converted to the desired
ynone through an <i>in situ</i> C–C bond oxidative
cleavage using molecular oxygen