Synthesis of Cyclic Imides from Nitriles and Diols
Using Hydrogen Transfer as a Substrate-Activating Strategy
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Abstract
An atom-economical
and versatile method for the synthesis of cyclic
imides from nitriles and diols was developed. The method utilizes
a Ru-catalyzed transfer-hydrogenation reaction in which the substrates,
diols, and nitriles are simultaneously activated into lactones and
amines in a redox-neutral manner to afford the corresponding cyclic
imides with evolution of H<sub>2</sub> gas as the sole byproduct.
This operationally simple and catalytic synthetic method provides
a sustainable and easily accessible route to cyclic imides