Schematic illustration of the proposed effects of rAg85B in a mouse model of allergic inflammation.

Abstract

<p>IFN-γ and IL-17-producing Th cells are induced in regional lymph nodes by rAg85B challenge, however, Th17 cells do not enter the lung unlike Th1 cells. Th17-related cytokine-secreting cells in lungs from rAg85B-administered mice are innate immune cells including γδT cells, IL-7R⁺ Lin⁻ cells, CD3⁻ NKp46⁺ cells and CD11c⁺ cells. IL-17 and IL-22 induced by rAg85B in an allergic environment have crucial roles in not only anti-allergic effects but also regulation of tissue homeostatic reactions.</p