IL-17A can activate p38 and NF-κB signal pathways in cervical cancer cells.

Abstract

<p>Expression of p38 and p-p38 were detected by western blot analysis in C33A(<b>A</b>) and Caski(<b>E</b>) cells treated with or without IL-17A for 24 hours. Quantification of the protein levels of p38 and p-p38 in C33A(<b>B</b>) and Caski(<b>F</b>). Values are represented as means ± SD of three independent experiments performed in triplicate. *p<0.05 and **p<0.01 compared with control group, respectively. Western blot analysis was used to detect nuclear p50 and p65 expression in C33A(<b>C</b>) and Caski(<b>G</b>) cells treated with IL-17A (50 ng/mL) at indicated time points. Quantification of the nuclear protein levels of p50 and p65 in C33A(<b>D</b>) and Caski(<b>H</b>) cells. Values are represented as means ± SD of three independent experiments performed in triplicate. * <i>p</i><0.05 and ** <i>p</i><0.01 compared with control group respectively.</p