NAC pretreatment promotes <i>V. cholerae</i> intestinal colonization and reduces the requirement for motility.

Abstract

<p>(A) Numbers of CFUs recovered from homogenates of the proximal (P), medial (M) and distal (D) segments of infant mice treated with PBS (black) or NAC (red) 30 minutes prior to inoculation with C6706 or <i>ΔmotB</i>. Bars represent the geometric mean. *P<0.05; Mann-Whitney test. (B) Confocal micrographs of tissue sections of the proximal SI from infant mice treated with PBS or NAC, 30 minutes prior to co-inoculation with VcGreen and VcRed. Scale bar = 50 µm. (C) Competition assays between GFP-labeled <i>ΔmotB</i> and VcRed in the P, M and D segments from mice treated with PBS or NAC 6 h prior to bacterial inoculation. Bars represent the geometric mean. ***P<0.001; Mann-Whitney test.</p

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