Heightened inflammation in GR ^{EC KO} mice following DEX pre-treatment.

Abstract

<p>(A) No differences in corticosterone level were observed between GR ^{EC KO} mice and controls for any of the conditions tested. (B) Total nitric oxide levels in GR ^{EC KO} mice are increased following DEX+LPS. (C) TNF-α and (D) IL-6 levels are significantly increased in GR ^{EC KO} mice following DEX+LPS treatment while they are nearly unchanged from baseline in controls. All blood samples were collected 8 hours after LPS treatment (and 10 hours after DEX pre-treatment, if applicable). *p<0.05 compared to similarly treated controls.</p