<p>Precision and recall values are compared in the B-cell lymphoma dataset (panel A) and Lung Adenocarcinoma dataset (panel B), calculated by matching the predictions with a gold standard dataset set obtained from four different databases of experimentally validated PPIs between modulators and transcription factors. Precision and recall are further compared at different robustness threshold for MINDy (blue line) and CINDy (red line) in the B-cell dataset (panel C) and in the Lung dataset (panel D, see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0109569#s4" target="_blank"><b>Materials and Methods</b></a>).</p