The proposed haem synthesis pathway in <i>Wolbachia</i>, showing structural intermediates.

Abstract

<p>Enzymes are represented by red boxes, which contain the protein name in <i>Wolbachia</i> and the abbreviated enzyme name: ALAS, 5-aminolevulinate synthase; ALAD, 5-aminolevulinate dehydratase; PBGB, porphobilinogen deaminase; UROS, uroporphyrinogen III synthase; UROD, uroporphyrinogen III decarboxylase; CPO, coproporphyrinogen III oxidase; PPO, protoporphyrinogen IX oxidase; FC, ferrochelatase. Inhibitors of the pathway are represented by blue boxes, for which abbreviations used are as in the text.</p