Di-<i>tert</i>-butyl
Peroxide-Promoted α‑Alkylation
of α‑Amino Carbonyl Compounds by Simple Alkanes
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Abstract
A di-<i>tert</i> butyl peroxide (DTBP)-promoted α-alkylation
of α-amino carbonyl compounds by simple alkanes is developed,
proceeding through dual sp<sup>3</sup> C–H bonds cleavage.
The reaction was applicable for α-amino ketones and α-amino
esters, providing a facile pathway for the α-functionalization
of these substrates. The radical pathway is involved in this transformation
