Developing Pd(II) Catalyzed Double sp³ C–H Alkoxylation for Synthesis of Symmetric and Unsymmetric Acetals

Abstract

An effective Pd­(II) catalyzed double unactivated C­(sp³)–H alkoxylation has been developed to prepare both symmetric and unsymmetric acetals. This new reaction demonstrates good functional group tolerance, excellent reactivity, and high yields. A variety of novel acetals can be readily accessed via this new method