ORP8 expression detected in murine atherosclerotic plaques correlates with expression of CD68.

Abstract

<p>mRNA was isolated from collar-induced plaques located in the carotid artery of LDLr KO mice. Samples were taken at 2 week intervals from week 2 baseline until week 12. Expression of ORP8 and the monocyte/macrophage marker CD68 was measured at each timepoint by microarray analysis and normalized for expression at baseline. A) ORP8 was found to be upregulated during plaque progression, as was CD68 (* P<0.05; $$<0.01, respectively). N = 3, values are expressed as mean ± SEM. Significance was assessed by ANOVA with Dunnetts post-test. B) Expression of ORP8 in murine atherosclerotic plaques correlated with expression of CD68 (P<0.001). Significance was assessed by linear regression.</p