Silver-Promoted Oxidative Cyclization of 1,6-Enynes:
Highly Regioselective Synthesis of Phosphorated Fluorene Derivatives
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Abstract
A silver-promoted
oxidative cyclization of 1,6-enynes with disubstituted
phosphine oxides is developed for the synthesis of fluorene derivatives.
The reaction proceeds with high regioselectivity by constructing one
C–P bond and two C–C bonds in one step. Moreover, reduction
of the pentavalent phosphine enlarges the application scope of the
product