Knockout of miR-34a expression enhanced the hepatoprotective effect of H₂S on the old rats.

Abstract

<p>(A) The serum levels of ALT and AST were assayed in the old rats. Pretreatment with NaHS had little effect on the serum levels of ALT and AST, which were significantly decreased by miR-34a inhibitor in the old rats with I/R. (B) The injection of miR-34a inhibitor clearly decreased miR-34a levels. (C) Suzuki’s scores for the livers of the old rats. **P<0.01, indicates significant differences from the respective control groups.</p