Model depicting network organization of the MAK-2 pathway and putative regulatory mechanisms.

Abstract

<p>Ligand-induced activation of an unknown receptor may be transmitted through plasma membrane-associated STE-20, RAS-2 and CAP-1, which signal toward the NRC-1/STE-50 complex and recruit the MAPK cascade through activation and clustering of the scaffold HAM-5 at intracellular puncta. MAK-2 activation triggers nuclear gene expression through interaction with the transcription factor PP-1 and the RCO-1/RCM-1 complex and the cytosolic activation of the secretory pathway and cell polarity machineries to coordinate pulsed signal release and chemotrophic growth towards the partner cell, respectively. MAK-2 activity is also required for termination of the receiver phase, potentially through negative feedback phosphorylation of the MAPK and disassembly of the MAK-2/HAM-5 module. MAK-2 pathway function may also be regulated through the STRIPAK complex, the CK2 heterodimer, membrane lipid composition, the septum-associated septation initiation network SIN and motor protein-dependent vesicle trafficking.</p

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