GSH is involved in the efflux of DDT and lindane in zebrafish embryos.

Abstract

<p>(A–B) Intracellular GSH contents in zebrafish embryos exposed to different concentrations of DDT or lindane from 96 to 120 hpf. (C–D) Contents of DDT or lindane in embryos after treatment with GSH at indicated concentrations for 24 hours. Embryos were exposed to medium containing 5 µg/L DDT or lindane and simultaneously to 0.1–5 µM GSH from 96 to 120 hpf. (E–F) Contents of DDT or lindane in embryos after treatment with BSO, an inhibitor of GSH biosynthesis, at indicated concentrations for 24 hours. Embryos were treated with medium containing 5 µg/L DDT or lindane and simultaneously with 1–25 µM BSO from 96 to 120 hpf. (<b>G–H</b>) ATPase activities as shown by Pi levels in 96-hpf embryos after exposure to DDT or lindane at indicated concentrations. Values are expressed as means ± standard deviations (n = 3). Significant differences are indicated by ^*<i>p</i><0.05 and ^**<i>p</i><0.01.</p