Design of DNA pooling with sample matching.

Abstract

<p>After sample matching and pool creation, the pools are grouped into <i>K</i> groups, with allele frequency in each group denoted by (<i>p</i>₁, …, <i>p_K</i>). Pools from the same groups are randomly distributed into <i>M</i> lanes, with sequencing errors (<i>e</i>₁, …, <i>e_M</i>).</p