Antiviral immune responses in CD4<sup>+</sup> T cell depleted mice.
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Abstract
<p>(<b>A</b>) Viral titers (4–6 mice/group), (<b>B</b>) albumin levels (4 mice/group), and (<b>C</b>) H1N1-specific IgM and IgG levels (4–6 mice/group) in C57BL/6 IFN-γ<sup>−/−</sup> and SOCS1<sup>−/−</sup>IFN-γ<sup>−/−</sup> airways after i.n. infection of 50 PFU PR8 influenza virus. Mice were injected i.p. with GK1.5 (anti-CD4) to deplete CD4<sup>+</sup> T cells. Control mice were treated with rat IgG. In (A), <i>P</i><0.001, ANOVA; *<i>P</i><0.05, **, <i>P</i><0.01, ***, <i>P</i><0.001, Tukey's multiple comparisons test, the data for each time point were repeated in at least two independent experiments. In (B), *<i>P</i><0.05, <i>t</i> test. Data in (B&C) are representative of two independent experiments.</p