IHC for DC-SIGN and DC-SIGNR expression in colon cancer tissues and in matched normal colonic mucosa of colon cancer patients.

Abstract

<p>Areas in the black boxes of <b>A</b>, <b>C</b>, <b>E</b>, <b>G</b>, <b>I</b><b>and</b><b><u>A</u></b>, <b><u>C</u></b>, <b><u>E</u></b>, <b><u>G</u></b><u>, <b>I</b></u> were enlarged below. <b>A-B</b>: DC-SIGN expression was detected in the internal border, central and peripheral part of colon carcinoma. <b>C–D</b>: blank control primary human colon cancer sections (without anti-DC-SIGN pAb). <b>E–F</b>: DC-SIGN expression in matched normal colonic mucosa. <b>G–H</b>: DC-SIGN expression was mainly detected in human lymphoid sinus. <b>I–J</b>: blank control human lymph node sections (without anti-DC-SIGN pAb); <b><u>A</u>–<u>B</u></b>: DC-SIGNR expression was weakly detected in the invasive margin of tumor. <b><u>C</u>–<u>D</u></b>: blank control primary human colon cancer sections. <b><u>E</u>–<u>F</u></b>: DC-SIGN expression was negative in matched normal colonic mucosa, while the <b><u>G</u></b> and <b><u>H</u></b> were positive controls in the human lymph node. <b><u>I</u>–<u>J</u></b>: blank control human lymph node sections. Magnification:100× in <b>A</b>, <b>C</b>, <b>E</b>,<u><b>A</b></u>, <b><u>C</u></b>, <b><u>E</u></b>, <b><u>G</u></b>,<u><b>I</b></u>; 200× in <b>G</b>, <b>I</b>; 400× in <b>B</b>, <b>D</b>, <b>F</b>, <b>H</b>, <b>J</b>, <b><u>B</u></b>, <b><u>D</u></b>, <b><u>F</u></b>, <b><u>H</u></b>, <b><u>J</u></b>.</p

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