The levels and diagnostic values of sDC-SIGN and sDC-SIGNR in colon cancer patients.
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Abstract
<p><b>A–B</b>: There was statistical significance in the sDC-SIGN and sDC-SIGNR level between healthy controls and colon cancer patients, P<0.001. The sDC-SIGN level (A) was lower in colon cancer patients than healthy controls; however, the sDC-SIGNR level (B) was higher in colon cancer patients than healthy controls. <b>C</b>: The level of sDC-SIGN in serum was significantly correlated with that of sDC-SIGNR in the same patient, P<0.001, r = 0.8137. <b>D–E</b>: According to the analysis of Youden index, the cut-off concentrations for sDC-SIGN and sDC-SIGNR are less than 2.226 µg/ml and more than 227.2 ng/ml, respectively, and the corresponding Sensitivity and Specificity of sDC-SIGN and sDC-SIGNR are 87.56%, 55.56% and 61.90%, 97.50%, respectively. Additionally, the Area under the curve (AUC) for sDC-SIGN is 0.7538, while the AUC of sDC-SIGNR is 0.8031. <b>F–G</b>: The AUC of CEA and CA19-9 in patients were 0.7477 and 0.6126, respectively. Based on the clinical decisive levels (0–5 ug/l for CEA, 0–27 U/ml for CA19-9), the cut-off values of CEA and CA19-9 were obtained. And the corresponding sensitivity and specificity of CEA and CA19-9 were 29.22 and 92.38, 14.67 and 94.55, respectively. <b>H</b>: The combined diagnosis of these two markers, sDC-SIGN and sDC-SIGNR, was analyzed through the binary logistic regression and ROC curve. The AUC of sDC-SIGN/sDC-SIGNR was 0.9885, the specificity and sensitivity were 94.8% and 98.7%, respectively.</p