Overexpression of CD90 in the stroma of pancreatic adenocarcinoma (PDAC).
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Abstract
<p>In both early (I and II) and late stages (III and IV) of PDACs, CD90 expression was highly increased, which was abundantly present in the activated stroma, including fibroblasts and vascular endothelial cells. The positive CD90<sup>+</sup> stromal cells were clustered around the malignant ducts. The circle insert in 3I showed a single layer of CD90<sup>+</sup> fibroblasts closely localized around tumor duct. The square inserts in 3I–3IV showed strong CD90 expression on vascular endothelial cells in PDAC stage I, II, III and IV, respectively.</p