Aβ(25-35) aggregation on DOPC/DHA lipid bilayer.
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Abstract
<p>(a-c) 5×2.2 µm<sup>2</sup> (1024×431px<sup>2</sup>) topographic AFM images of Aβ(25-35) aggregation on DOPC/DHA lipid bilayers. (d) Graph showing the increasing surface area covered by LA (blue line) and the lipid bilayer evolution over time (red line). LA structures were grown within the first 30 min of peptide deposition while the lipid surface area decreased slowly from 96% to 91%. Data were qualitatively fitted by rational and sigmoidal functions for the DOPC/DHA bilayer (Θ<sub>DOPC/DHA</sub>) and the LA domains (Θ<sub>P</sub>), respectively. Fitting curves act as guide-to-the-eye. (e) Height distribution histograms measured at t = 0 min (black), 30 min (red), 1 h (green), 1 h45 min (blue), 2 h (cyan) and 2 h20 min (magenta).</p
