<p>A) A histogram showing the number of putative CRP binding sites in each of 7 discrete bins. Each bin is delineated by the “score” of the putative CRP site. A high score indicates a better match to the Position Weight Matrix that represents the consensus for CRP binding. B) The graph illustrates binding of CRP to a target from each of the bins shown in Panel A. CRP was used at concentrations of 0, 175, 350 or 700 nM. C) ChIP-seq data for CRP and H-NS binding at five regions of plasmids p666 and p948 that contain unoccupied CRP targets bound by CRP <i>in vitro</i>. The CRP and H-NS binding profiles are plots of sequence read counts at each position of the genome on both the top (above the central line) and bottom (below the central line) strand of the DNA. The y-axis scale is the same in each panel. The scale for H-NS binding is 1,785 reads on each strand and for CRP binding is 14,000 reads on each strand.</p
