An antagonist of PI3Kδ inhibits both chemotactic and chemokinetic migration mediated by CXCL8 and GM-CSF-.

Abstract

<p>Neutrophils were treated with 1μM and 10μM of the PI3Kδ selective inhibitor PIK-274 for 30 mins prior to the addition of CXCL8 (100ng/ml, a) or 0.5ng/ml GM-CSF (b). Data shown are mean ±SEM (n = 3) except for gradient DMSO and 1μM of PIK-274 where n = 8. *p<0.05, ***p<0.001.</p