An antagonist of PI3Kγ inhibits CXCL8 mediated chemokinetic but not chemotactic migration and GM-CSF mediated chemokinetic migration at a sub-optimal concentration of GM-CSF.

Abstract

<p>Neutrophils were treated with 10μM PI3Kγ selective inhibitor for 30 mins prior to the addition of CXCL8 (100ng/ml, a) or GM-CSF (0.5ng/ml, 50ng/ml, b). Data shown are mean ±SEM (n = 3) except for non gradient CXCL8 where n = 4 and GM-CSF where n = 6 ***p<0.001.</p