Selective
Ion Exchange Governed by the Irving–Williams
Series in K<sub>2</sub>Zn<sub>3</sub>[Fe(CN)<sub>6</sub>]<sub>2</sub> Nanoparticles: Toward a Designer Prodrug for Wilson’s Disease
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Abstract
The
principle of the Irving–Williams series is applied to the design
of a novel prodrug based on K<sub>2</sub>Zn<sub>3</sub>[Fe(CN)<sub>6</sub>]<sub>2</sub> nanoparticles (ZnPB NPs) for Wilson’s
disease (WD), a rare but fatal genetic disorder characterized by the
accumulation of excess copper in the liver and other vital organs.
The predetermined ion-exchange reaction rather than chelation between
ZnPB NPs and copper ions leads to high selectivity of such NPs for
copper in the presence of the other endogenous metal ions. Furthermore,
ZnPB NPs are highly water-dispersible and noncytotoxic and can be
readily internalized by cells to target intracellular copper ions
for selective copper detoxification, suggesting their potential application
as a new-generation treatment for WD
