Suppression of Dicer leads to a glomerulocystic disease.

Abstract

<p>Representative pictures of hematoxylin and eosin (A-F) and Masson’s Trichrome (G,I). Staining of Ctr (A, D, G), Dicer cKO kidneys at P30 (B, E, H) and Dicer cKO kidneys at P50 (C, F, I). Dicer induced cyst formation is limited to the cortex (C). Dicer cKO mice present a glomerulocystic phenotype and tubular dilatation at P50 (F). These alterations are not so prominent at P30, where only sites of dilatation in Bowman capsule can be sporadically seen (E). Interstitial fibrosis is evident in Dicer cKO mice at P50 (I). (A, B, C) Magnification 5X. (D- I) Magnification 40X.</p