TEVG implantation was successful as indicated by a similar survival rate at 12-month post-operation in TEVG group to sham group.

Abstract

<p>A. Structure of TEVG. Implanted TEVG was composed of biodegradable electrospun polylactic acid (PLA) nanofibers with a length of approximately 3mm and inner luminal diameter 500–600 μm. Scanning electron microscopy demonstrates macro- and micro-arrangement of graft. <b>B.</b> TEVG after surgical implantation (IVC: inferior vena cava; Ao: aorta). <b>C.</b> Survival rate at 24 hours after surgery. 25 TEVGs were implanted in C17SCID/bg mice. 12 syngeneic mice underwent sham operations. >90% of mice implanted with TEVG survived 24 hours after TEVG implantation. Peri-operative mortality was due to bleeding or thrombosis. <b>D.</b> Kaplan-Meier survival curve during the 12 months of experiment. Similar survival rate was seen between two groups over the course of 12 month-experiment.</p