Abstract

<p>Representative slides of liver (A, B) and spleen (D, E) hematoxylin and-eosin (HE) staining of wildtype (WT) and <i>S100A9</i><sup><i>-/-</i></sup> mice, 5 days post infection. Liver and spleen from both WT and <i>S100A9</i><sup><i>-/-</i></sup> mice displayed advanced inflammation with necrosis (#) and thrombosis (*). Magnification 10 ×. Total pathology score was determined at indicated time points in WT (white bars) and <i>S100A9</i><sup><i>-/-</i></sup> (grey bars) mice according to the scoring system described in the methods section (C, F). Aspartate aminotransferase (AST; G), alanine aminotransferase (ALT; H), and lactate dehydrogenase (LDH; I) were measured in plasma. Data are expressed as box-and-whisker diagrams depicting the smallest observation, lower quartile, median, upper quartile and largest observation (5–8 mice per group at each time point).</p

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