Influence of temperature on potentiation of Compound B responses by PNU-120596.

Abstract

<p>A) Representative FLIPR traces showing the change in fluorescence observed when compound B (1 μM) and PNU-120596 (100 μM) were co-applied to iPSC-derived neurons at room temperature (RT) (closed circles) and at 37°C (open circles). B) Concentration-response relationship of PNU-120596 in the presence of compound B (1 μM) at room temperature (RT) and at 37°C. Data points are means of 4 independent experiments each of which generated paired data from the same batch of cells incubated at two temperatures.</p