Effect of different concentrations of mithramycin on the regulation of Sp1, collagen Iexpression and signal transduction in CFs.

Abstract

<p>A-F: Western blots and analysis of mithramycin on the regulation of Sp1 (A), collagen I (B), TGF-β (C), p-ERK (D), p-JNK (E) and p-p38 (F). Con: normal untreated CFs; NC: negative control siRNA; M: mithramycin. *p < 0.05, compared with control; and #p < 0.05, compared with NC.</p