<i>Let-7b</i> selectively downregulates mutant KRAS expression.

Abstract

<p>The endogenous levels of <i>let-7b</i> (A), KRAS mRNA (B) and KRAS protein (C) in NIH-H1975, A549, BxPC-3 and Panc-1 cells. The expression of <i>let-7b</i> (D), KRAS protein (E) and KRAS mRNA (F) in the cells transfected with <i>let-7b</i> mimic alone or in combination with PTX or GEM. Each experiment was carried out at least 3 times. Data represent the mean ±SEM. *, <i>p</i> < 0.05; **, <i>p</i> < 0.01.</p