<p>We retrieved 17 GWAS studies, 18 proteomics studies and 19 metabolomics studies that assessed diabetes patients until August 2014. 115 genes, 56 proteins and 227 metabolites were significantly associated with diabetes. An HMDB search revealed 1660 metabolite-protein pairs corresponding to 840 proteins. Overall, 992 unique proteins associated with diabetes were gathered and mapped to the TTD database and 108 of them had drug projects information. After removing those under experimental and preclinical stages, we obtained 35 protein targets, including 5 known anti-diabetic targets (27 drugs projects) and 30 unknown anti-diabetic targets (167 drugs projects). Pathogenesis knowledge was retrieved from the OMIM and Pubmed databases, 12 targets corresponding to 58 drugs were indicated to have novel indication for diabetes treatment. CMap analysis indicated that 9 of the 58 drugs have the potential to treat diabetes.</p
