Abstract

<p>For CAT and MNs quantification in tissue 63 patients were enrolled and 66 tumors were collected (two patients had bilateral tumors (P21 and P43) and one had both a PHEO and a PGL (P25)*, see also <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0125426#pone.0125426.t001" target="_blank">Table 1</a>. Tumors consisted of 53 PHEO and 13 PGL. Quantification of CAT in plasma was performed on 72 patients from 50 PHEO and 23 PGL patients, (including P25 with both a PHEO and a PGL). The plasma CAT analysis was performed on the same patient recruited for tissue CAT and MNs study with the following exceptions: two plasma were not available (P14 and P27) and two tumors were bilaterally excised at the same time (P43 and P44), finally, 10 additional plasma from PGL patients were added in the study without tissue sample available. For MNs quantification in plasma, sample P62 was not available (instead of P27 for CAT). Three tissue samples for PHEO and two for PGL were stored in perchloric acid, not compatible for mRNA extraction for qPCR assay**. 15 PHEO tissue sample were no longer available for WB assays***.</p

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