<p>ITC experiments were performed by titrating KCTD6<sup><b>BTB</b></sup> (A), KCTD11<sup><b>BTB</b></sup> (B), KCTD12<sup><b>BTB</b></sup> (C) with Cul3<sup><b>NTD</b></sup>. For KCTD15<sup><b>BTB</b></sup> the ITC experiment was reversed by titrating Cul3<sup><b>NTD</b></sup> with KCTD15<sup><b>BTB</b></sup> (D). The top and bottom panels report raw and integrated data, respectively.</p